©2024 - Stefano Forte
EV based liquid Biopsy - The role in EVs in cacner
Extracellular vesicles (EVs) are key mediators of cell-to-cell communication and play an active role in tumor progression, metastasis, and treatment resistance. Our research focuses on understanding their biological function and translating this knowledge into clinically relevant applications.
A central aspect of our work is the characterization of EV-associated molecular profiles to capture tumor-derived signals in a minimally invasive manner. By integrating advanced analytical approaches with clinically oriented study designs, we aim to identify functional biomarkers that reflect tumor dynamics and support patient stratification.
These efforts are embedded within the broader framework of liquid biopsy, where EVs represent a complementary and, in some contexts, highly informative source of tumor-derived material. By bridging experimental models and clinical data, we contribute to the development of predictive tools that combine biological relevance with practical applicability in real-world settings.
Extracellular vesicle-based liquid biopsy for prostate cancer detection
In this study, we developed a liquid biopsy approach based on the analysis of protein signatures associated with extracellular vesicles isolated from blood samples. By evaluating specific combinations of intra-vesicular and surface proteins, we identified EV-derived profiles capable of distinguishing prostate cancer patients from individuals with benign prostatic hyperplasia. This work highlights the potential of EV-based assays to improve the specificity of current diagnostic strategies, offering a non-invasive approach that may complement existing tools and support more accurate clinical decision-making.
👉 Read the full article: Extracellular vesicle protein signatures prostate cancer Cells 2024
Extracellular vesicle-based liquid biopsy for prostate cancer detection
In parallel, our work has explored the broader role of extracellular vesicles within the liquid biopsy landscape. This study provides an overview of the biological and technological foundations underlying EV-based analyses, discussing their potential application in early detection, disease monitoring, and prediction of therapeutic response. Particular attention is given to current limitations and methodological challenges, highlighting the need for robust and standardized approaches to fully translate EV research into clinical practice.
👉 Read the full article: Extracellular vesicles liquid biopsy review Biomolecules 2024
©2024 - Stefano Forte